Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness
Metabolic cycles are a fundamental element of cellular and organismal function.Among the most critical in higher organisms is the Cori Cycle, the systemic cycling between lactate and glucose.Here, skeletal muscle-specific Mitochondrial Pyruvate copyright (MPC) deletion in mice diverted pyruvate into circulating lactate.This switch disinhibited musc