IMPAIRED SKELETAL MUSCLE MITOCHONDRIAL PYRUVATE UPTAKE REWIRES GLUCOSE METABOLISM TO DRIVE WHOLE-BODY LEANNESS

Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness

Metabolic cycles are a fundamental element of cellular and organismal function.Among the most critical in higher organisms is the Cori Cycle, the systemic cycling between lactate and glucose.Here, skeletal muscle-specific Mitochondrial Pyruvate copyright (MPC) deletion in mice diverted pyruvate into circulating lactate.This switch disinhibited musc

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The P3N-PIPO Protein Encoded by Wheat Yellow Mosaic Virus Is a Pathogenicity Determinant and Promotes Its Pathogenicity through Interaction with NbRLK6 in Nicotiana benthamiana

Similarly to other potyvirids, the bymovirus wheat yellow mosaic virus (WYMV) encodes a P3N-PIPO protein that is expressed by frameshifting occurring within the open reading frame napoleon concealer of the P3 protein.P3N-PIPO is known to be essential for the cell-to-cell movement of several potyviruses, but this has not yet been confirmed for the W

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Examining the impact of nanotechnology on medical and environmental sciences from the nanometric tools perspective

The idea of the technology of read more molecular engineering or nanotechnology was first proposed by Richard Fieman in 1959.Nanotechnology is, in essence, the technology of breaking down the molecular structures with an atomic precision.The strategic significance of this technology and its relations with minute particles in medical and environment

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